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Adrenergic augmentation of cardiac contractility requires Rad phosphorylation - Nature Cardiovascular Research

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Adrenergic augmentation of cardiac contractility requires Rad phosphorylation - Nature Cardiovascular Research

The mechanisms of adrenergic stimulation of cardiac voltage-gated calcium (CaV) channels have remained elusive. Using proximity proteomics and genetically altered mice, we show that phosphorylation of the CaV channel inhibitor Rad is essential for regulation, by the sympathetic nervous system, of calcium influx, and for augmentation of cardiac contractility.

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Adrenergic augmentation of cardiac contractility requires Rad phosphorylation - Nature Cardiovascular Research

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Adrenergic augmentation of cardiac contractility requires Rad phosphorylation - Nature Cardiovascular Research

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