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Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency - Nature Microbiology

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Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency - Nature Microbiology

After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a genome-wide CRISPR/Cas9 knockout screen, we identified the host SMC5/6 complex as essential for this epigenetic silencing. We show that SMC5/6 binds to and then SUMOylates unintegrated chromatinized HIV-1 DNA.

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Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency - Nature Microbiology

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Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency - Nature Microbiology

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