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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury - Nature Neuroscience

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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury - Nature Neuroscience

Decreasing the activation of pathology-activated microglia is crucial to prevent chronic inflammation and tissue scarring. In this study, we used a stab wound injury model in zebrafish and identified an injury-induced microglial state characterized by the accumulation of lipid droplets and TAR DNA-binding protein of 43 kDa (TDP-43)+ condensates.

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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury - Nature Neuroscience

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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury - Nature Neuroscience

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