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Insights into distinct signaling profiles of the µOR activated by diverse agonists - Nature Chemical Biology

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Insights into distinct signaling profiles of the µOR activated by diverse agonists - Nature Chemical Biology

Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression through a pathway that remains unclear. Here we investigated the mechanistic basis of action of lofentanil (LFT) and mitragynine pseudoindoxyl (MP), two μOR agonists with different safety profiles.

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Insights into distinct signaling profiles of the µOR activated by diverse agonists - Nature Chemical Biology

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Insights into distinct signaling profiles of the µOR activated by diverse agonists - Nature Chemical Biology

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