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Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion - Nature

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Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion - Nature

High cholesterol is a major risk factor for cardiovascular disease1. Currently, no drug lowers cholesterol through directly promoting cholesterol excretion. Human genetic studies have identified that the loss-of-function Asialoglycoprotein receptor 1 (ASGR1) variants associate with low cholesterol and a reduced risk of cardiovascular disease2. ASGR1 is exclusively expressed in liver and mediates internalization and lysosomal degradation of blood asialoglycoproteins3.

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Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion - Nature

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Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion - Nature

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