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PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis - Nature Communications

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PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis - Nature Communications

Pulmonary fibrosis is a chronic interstitial lung disease that causes irreversible and progressive lung scarring and respiratory failure. Activation of fibroblasts plays a central role in the progression of pulmonary fibrosis. Here we show that platelet endothelial aggregation receptor 1 (PEAR1) in fibroblasts may serve as a target for pulmonary fibrosis therapy. Pear1 deficiency in aged mice spontaneously causes alveolar collagens accumulation.

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PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis - Nature Communications

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PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis - Nature Communications

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