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Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice - Nature Aging

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Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice - Nature Aging

Aging is characterized by an accumulation of myeloid-biased hematopoietic stem cells (HSCs) with reduced developmental potential. Genotoxic stress and epigenetic alterations have been proposed to mediate age-related HSC loss of regenerative and self-renewal potential. However, the mechanisms underlying these changes remain largely unknown. Genetic inactivation of the plant homeodomain 6 (Phf6) gene, a nucleolar and chromatin-associated factor, antagonizes age-associated HSC decline.

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Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice - Nature Aging

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Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice - Nature Aging

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