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Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancer - npj Breast Cancer

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Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancer - npj Breast Cancer

We evaluate microsatellite instability-high (MSI-H) status with cell-free DNA (cfDNA) in metastatic breast cancer (MBC) and the association with clinico-genomic characteristics. Patients with MSI-H in cfDNA (Guardant360®, 74 gene next-generation sequencing (NGS) with MBC are identified. We conduct a retrospective review. The median number of alterations and a median maximum mutant allelic fraction (MAF) in MSI-H and non-MSI-H cohorts are compared with Mann–Whitney U-test.

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Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancer - npj Breast Cancer

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Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancer - npj Breast Cancer

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