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Histone H3 proline 16 hydroxylation regulates mammalian gene expression - Nature Genetics

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Histone H3 proline 16 hydroxylation regulates mammalian gene expression - Nature Genetics

Histone post-translational modifications (PTMs) are important for regulating various DNA-templated processes. Here, we report the existence of a histone PTM in mammalian cells, namely histone H3 with hydroxylation of proline at residue 16 (H3P16oh), which is catalyzed by the proline hydroxylase EGLN2.

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gene expression histone mammalian histone h3 hydroxylation proline science biology genetics

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Histone H3 proline 16 hydroxylation regulates mammalian gene expression - Nature Genetics

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Histone H3 proline 16 hydroxylation regulates mammalian gene expression - Nature Genetics

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