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Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells - Nature Chemical Biology

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Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells - Nature Chemical Biology

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce pyroptosis of HIV-1-infected CD4+ T cells through induction of intracellular HIV-1 protease activity, which activates the CARD8 inflammasome. Because high concentrations of NNRTIs are required for efficient elimination of HIV-1-infected cells, it is important to elucidate ways to sensitize the CARD8 inflammasome to NNRTI-induced activation.

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Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells - Nature Chemical Biology

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Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells - Nature Chemical Biology

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