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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor - Nature Chemistry

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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor - Nature Chemistry

G-protein-coupled receptors signal through cognate G proteins. Despite the widespread importance of these receptors, their regulatory mechanisms for G-protein selectivity are not fully understood. Here we present a native mass spectrometry-based approach to interrogate both biased signalling and allosteric modulation of the β1-adrenergic receptor in response to various ligands.

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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor - Nature Chemistry

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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor - Nature Chemistry

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