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Anionic lipids unlock the gates of select ion channels in the pacemaker family - Nature Structural & Molecular Biology

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Anionic lipids unlock the gates of select ion channels in the pacemaker family - Nature Structural & Molecular Biology

Lipids play important roles in regulating membrane protein function, but the molecular mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a bacterial pacemaker channel homolog, and HCN2, whose activity contributes to pacemaking in the heart and brain. Using SthK allowed the reconstitution of purified channels in controlled lipid compositions for functional and structural assays that are not available for the eukaryotic channels.

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Anionic lipids unlock the gates of select ion channels in the pacemaker family - Nature Structural & Molecular Biology

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Anionic lipids unlock the gates of select ion channels in the pacemaker family - Nature Structural & Molecular Biology

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