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An atypical RNA quadruplex marks RNAs as vectors for gene silencing - Nature Structural & Molecular Biology

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An atypical RNA quadruplex marks RNAs as vectors for gene silencing - Nature Structural & Molecular Biology

The addition of poly(UG) ('pUG') repeats to 3′ termini of mRNAs drives gene silencing and transgenerational epigenetic inheritance in the metazoan Caenorhabditis elegans. pUG tails promote silencing by recruiting an RNA-dependent RNA polymerase (RdRP) that synthesizes small interfering RNAs. Here we show that active pUG tails require a minimum of 11.5 repeats and adopt a quadruplex (G4) structure we term the pUG fold.

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An atypical RNA quadruplex marks RNAs as vectors for gene silencing - Nature Structural & Molecular Biology

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An atypical RNA quadruplex marks RNAs as vectors for gene silencing - Nature Structural & Molecular Biology

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