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Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis - Cell Death Discovery
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Overproduction of reactive oxygen species (ROS) and aberrant lipid metabolism are established hallmarks of cancer; however, the role of ROS in lipid synthesis during tumorigenesis is almost unknown. Herein, we show that ROS regulates lipid synthesis and thus controls colorectal tumorigenesis through a p53-dependent mechanism.
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