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ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues - Cell Death Discovery

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ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues - Cell Death Discovery

Enhancer release and retargeting (ERR) events could activate disease-causing gene promoters for increasing the expression level of oncogenes. Meanwhile, class A orphan GPCRs (oGPCRs) are known as potential biomarkers or drug targets for various cancers, such as gastric cancer (GC). Hence, systemic investigation of ERR events for class A oGPCRs in GC could help to explore biomarkers for GC. In this study, ENCODE and GTEx eQTL data were utilized to define ERR events in GC.

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ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues - Cell Death Discovery

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ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues - Cell Death Discovery

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