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Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA - Cell Death & Disease

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Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA - Cell Death & Disease

Serine/arginine-rich splicing factor 3 (SRSF3) is an RNA binding protein that most often regulates gene expression at the splicing level. Although the role of SRSF3 in mRNA splicing in the nucleus is well known, its splicing-independent role outside of the nucleus is poorly understood. Here, we found that SRSF3 exerts a translational control of p21 mRNA. Depletion of SRSF3 induces cellular senescence and increases the expression of p21 independent of p53.

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Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA - Cell Death & Disease

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Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA - Cell Death & Disease

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