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ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP - Nature Metabolism

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ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP - Nature Metabolism

Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis1. Aside from cAMP signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood. Here, we show that coordinated α1-adrenergic receptor (AR) and β3-AR signalling induces the expression of thermogenic genes of the futile creatine cycle2,3, and that early B cell factors, oestrogen-related receptors and PGC1α are required for this response in vivo.

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ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP - Nature Metabolism

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ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP - Nature Metabolism

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