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Endocrine resistance and breast cancer plasticity are controlled by CoREST - Nature Structural & Molecular Biology

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Endocrine resistance and breast cancer plasticity are controlled by CoREST - Nature Structural & Molecular Biology

Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that the CoREST complex is a key determinant of endocrine resistance and ER+ breast cancer plasticity. In endocrine-sensitive cells, CoREST is recruited to regulatory regions co-bound to ERα and FOXA1 to regulate the estrogen pathway. In contrast, during temporal reprogramming towards a resistant state, CoREST is recruited to AP-1 sites.

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Endocrine resistance and breast cancer plasticity are controlled by CoREST - Nature Structural & Molecular Biology

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Endocrine resistance and breast cancer plasticity are controlled by CoREST - Nature Structural & Molecular Biology

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