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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD - Nature

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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD - Nature

Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has demonstrated dysregulation at the molecular level, characterized by transcriptomic and epigenetic alterations1–3. In autism spectrum disorder (ASD), this molecular pathology involves the upregulation of microglial, astrocyte and neural–immune genes, the downregulation of synaptic genes, and attenuation of gene-expression gradients in cortex1,2,4–6.

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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD - Nature

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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD - Nature

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