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Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes - Nature

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Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes - Nature

The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulation and its potential as a target to ameliorate the ageing process. Here we show that senescent cells heterogeneously express the immune checkpoint protein programmed death-ligand 1 (PD-L1) and that PD-L1+ senescent cells accumulate with age in vivo.

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Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes - Nature

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Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes - Nature

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