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SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas - npj Precision Oncology

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SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas - npj Precision Oncology

Rare gain-of-function mutations in RAC1 drive drug resistance to targeted BRAF inhibition in cutaneous melanoma. Here, we show that wildtype RAC1 is a critical driver of growth and drug resistance, but only in a subset of melanomas with elevated markers of de-differentiation. Similarly, SRC inhibition also selectively sensitized de-differentiated melanomas to BRAF inhibition.

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SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas - npj Precision Oncology

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SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas - npj Precision Oncology

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