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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor - Nature Chemical Biology

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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor - Nature Chemical Biology

The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter primary sensory neurons and involved in the mediation of nociception and pruritus. Central activation of MRGPRX1 by the endogenous opioid peptide fragment BAM8-22 and its positive allosteric modulator ML382 has been shown to effectively inhibit persistent pain, making MRGPRX1 a promising target for non-opioid pain treatment.

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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor - Nature Chemical Biology

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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor - Nature Chemical Biology

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