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Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota - Nature Immunology

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Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota - Nature Immunology

Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define their phenotypes or determine their heterogeneity. By single-cell mRNA sequencing, cytometry and a genetic pulse–chase mouse model, we show that IgG and IgM LLPCs display an EpCAMhiCXCR3– phenotype, whereas IgA LLPCs are Ly6AhiTigit–.

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Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota - Nature Immunology

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Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota - Nature Immunology

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