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Genome-wide polygenic score to predict chronic kidney disease across ancestries - Nature Medicine

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Genome-wide polygenic score to predict chronic kidney disease across ancestries - Nature Medicine

Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been optimized for ancestrally diverse populations. By combining APOL1 risk genotypes with genome-wide association studies (GWAS) of kidney function, we designed, optimized and validated a genome-wide polygenic score (GPS) for CKD.

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Genome-wide polygenic score to predict chronic kidney disease across ancestries - Nature Medicine

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Genome-wide polygenic score to predict chronic kidney disease across ancestries - Nature Medicine

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