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CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology - Nature Immunology

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CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology - Nature Immunology

Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here we show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor (IL-17R). CMTM4 constitutively associated with IL-17R subunit C to mediate its stability, glycosylation and plasma membrane localization.

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CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology - Nature Immunology

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CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology - Nature Immunology

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