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The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis - Nature Cell Biology

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The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis - Nature Cell Biology

Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups) that regulate the selective passage of biomolecules across the nuclear envelope. The FG-Nups are intrinsically disordered and prone to liquid–liquid phase separation and aggregation when isolated. How FG-Nups are protected from making inappropriate interactions during NPC biogenesis is not fully understood. Here we

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The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis - Nature Cell Biology

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The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis - Nature Cell Biology

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