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NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart - Nature Communications

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NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart - Nature Communications

To adapt to changing hemodynamic demands, regulatory mechanisms modulate actin-myosin-kinetics by calcium-dependent and -independent mechanisms. We investigate the posttranslational modification of human essential myosin light chain (ELC) and identify NIMA-related kinase 9 (NEK9) to interact with ELC. NEK9 is highly expressed in the heart and the interaction with ELC is calcium-dependent. Silencing of NEK9 results in blunting of calcium-dependent ELC-phosphorylation.

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NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart - Nature Communications

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NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart - Nature Communications

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