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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor - Nature Communications

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor - Nature Communications

The zinc-dependent metalloprotease meprin α is predominantly expressed in the brush border membrane of proximal tubules in the kidney and enterocytes in the small intestine and colon. In normal tissue homeostasis meprin α performs key roles in inflammation, immunity, and extracellular matrix remodelling. Dysregulated meprin α is associated with acute kidney injury, sepsis, urinary tract infection, metastatic colorectal carcinoma, and inflammatory bowel disease.

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor - Nature Communications

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor - Nature Communications

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