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Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice - Nature Metabolism

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Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice - Nature Metabolism

Cysteine dioxygenase 1 (Cdo1) is a key enzyme in taurine synthesis. Here we show that Cdo1 promotes lipolysis in adipose tissue. Adipose-specific knockout of Cdo1 in mice impairs energy expenditure, cold tolerance and lipolysis, exacerbates diet-induced obesity (DIO) and decreases adipose expression of the key lipolytic genes encoding ATGL and HSL, with little effect on adipose taurine levels.

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Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice - Nature Metabolism

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Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice - Nature Metabolism

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