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Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector - Scientific Reports

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Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector - Scientific Reports

Human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors are indispensable tools for gene engineering in mammalian cells. Conversely, lentiviral vector transduction is severely inhibited in bovine cells. Previous studies demonstrated that this inhibition is caused by the anti-lentiviral host factor tripartite motif containing 5 (TRIM5), which targets incoming HIV-1 virions by interacting with the viral capsid.

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Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector - Scientific Reports

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Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector - Scientific Reports

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