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Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer's disease - Neuropsychopharmacology

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Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer's disease - Neuropsychopharmacology

Alzheimer's disease (AD) is the most common neurodegenerative disease and has an insidious onset. Exploring the characteristics and mechanism of the early symptoms of AD plays a critical role in the early diagnosis and intervention of AD. Here we found that depressive-like behavior and short-term spatial memory dysfunction appeared in APPswe/PS1dE9 mice (AD mice) as early as 9-11 weeks of age.

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Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer's disease - Neuropsychopharmacology

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Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer's disease - Neuropsychopharmacology

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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