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Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice - Cell Death & Disease

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Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice - Cell Death & Disease

Human genetic and animal model studies indicate that brain microglial inflammation is a primary driver of cognitive impairment in Alzheimer Disease (AD). Inflammasome-activated Caspase-1 (Casp1) is associated with both AD microglial inflammation and neuronal degeneration. In mice, Casp1 genetic ablation or VX-765 small molecule inhibition of Casp1 given at onset of cognitive deficits strongly supports the association between microglial inflammation and cognitive impairment.

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Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice - Cell Death & Disease

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Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice - Cell Death & Disease

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