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IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohort - Genes & Immunity

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IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohort - Genes & Immunity

IgG3 would play an important role in the immune adaptive response against SARS-CoV-2, and low plasma levels might increase the risk of COVID-19 severity and mortality. The IgG3 hinge sequence has a variable repeat of a 15 amino acid exon with common 4-repeats (M) and 3-repeats (S). This length IGHG3 polymorphism might affect the IgG3 effector functions. The short hinge length would reduce the IgG3 flexibility and impairs the neutralization and phagocytosis compared to larger length-isoforms.

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IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohort - Genes & Immunity

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IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohort - Genes & Immunity

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