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Isatropolone/isarubrolone Cm from Streptomyces with biological activity of inducing incomplete autophagy - The Journal of Antibiotics

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Isatropolone/isarubrolone Cm from Streptomyces with biological activity of inducing incomplete autophagy - The Journal of Antibiotics

Isatropolones/isarubrolones are Streptomyces secondary metabolites featuring a tropolone ring in the pentacyclic scaffolds of these molecules. They are able to induce complete autophagy in human HepG2 cells. Here, methyl isatropolones (1–2) and isarubrolone (3) are identified from Streptomyces CPCC 204095. They all have a methyl tropolone ring in the pentacyclic scaffold of these molecules resolved by MS and NMR spectra.

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Isatropolone/isarubrolone Cm from Streptomyces with biological activity of inducing incomplete autophagy - The Journal of Antibiotics

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Isatropolone/isarubrolone Cm from Streptomyces with biological activity of inducing incomplete autophagy - The Journal of Antibiotics

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