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DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells - Leukemia

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DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells - Leukemia

Myeloid malignancies with DDX41 mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the mechanisms underlying these specific conditions remain elusive. Here, we demonstrate that loss of DDX41 function impairs efficient RNA splicing, resulting in DNA replication stress with excess R-loop formation.

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DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells - Leukemia

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DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells - Leukemia

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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