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Actinomycetes-derived imine reductases with a preference towards bulky amine substrates - Communications Chemistry

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Actinomycetes-derived imine reductases with a preference towards bulky amine substrates - Communications Chemistry

Since imine reductases (IREDs) were reported to catalyze the reductive amination reactions, they became particularly attractive for producing chiral amines. Though diverse ketones and aldehydes have been proved to be excellent substrates of IREDs, bulky amines have been rarely transformed. Here we report the usage of an Increasing-Molecule-Volume-Screening to identify a group of IREDs (IR-G02, 21, and 35) competent for accepting bulky amine substrates.

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Actinomycetes-derived imine reductases with a preference towards bulky amine substrates - Communications Chemistry

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Actinomycetes-derived imine reductases with a preference towards bulky amine substrates - Communications Chemistry

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