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Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors - Nature Biotechnology

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Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors - Nature Biotechnology

Bacterial toxin DddA-derived cytosine base editors (DdCBEs)—composed of split DddAtox (a cytosine deaminase specific to double-stranded DNA), custom-designed TALE (transcription activator-like effector) DNA-binding proteins, and a uracil glycosylase inhibitor—enable mitochondrial DNA (mtDNA) editing in human cells, which may pave the way for therapeutic correction of pathogenic mtDNA mutations in patients.

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Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors - Nature Biotechnology

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Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors - Nature Biotechnology

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