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Sterol homeostasis in yeast - Nature Chemical Biology

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Sterol homeostasis in yeast - Nature Chemical Biology

The fungal sterol receptor and transcription factor Upc2 activates the transcription of ergosterol biosynthesis genes in response to ergosterol depletion in yeast. A structural and biochemical study reveals an Hsp90-dependent translocation activation mechanism of Upc2, with implications for triazole antifungal resistance.

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Sterol homeostasis in yeast - Nature Chemical Biology

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Sterol homeostasis in yeast - Nature Chemical Biology

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