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Structural basis for activation of fungal sterol receptor Upc2 and azole resistance - Nature Chemical Biology

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Structural basis for activation of fungal sterol receptor Upc2 and azole resistance - Nature Chemical Biology

Fungal transcription factor Upc2 senses ergosterol levels and regulates sterol biosynthesis and uptake. Constitutive activation of Upc2 causes azole resistance in Candida species. We determined the structure of ergosterol-bound Upc2, revealing the ligand specificity and transcriptional regulation. Ergosterol binding involves conformational changes of the ligand-binding domain, creating a shape-complementary hydrophobic pocket.

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Structural basis for activation of fungal sterol receptor Upc2 and azole resistance - Nature Chemical Biology

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Structural basis for activation of fungal sterol receptor Upc2 and azole resistance - Nature Chemical Biology

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