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Activation of γ-globin expression by hypoxia-inducible factor 1α - Nature

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Activation of γ-globin expression by hypoxia-inducible factor 1α - Nature

Around birth, globin expression in human red blood cells (RBCs) shifts from γ-globin to β-globin, which results in fetal haemoglobin (HbF, α2γ2) being gradually replaced by adult haemoglobin (HbA, α2β2)1. This process has motivated the development of innovative approaches to treat sickle cell disease and β-thalassaemia by increasing HbF levels in postnatal RBCs2.

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Activation of γ-globin expression by hypoxia-inducible factor 1α - Nature

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Activation of γ-globin expression by hypoxia-inducible factor 1α - Nature

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