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Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome - Nature Structural & Molecular Biology

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Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome - Nature Structural & Molecular Biology

SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high-resolution crystal structure of the SHOC2–MRAS–PP1C (SMP) complex and apo-SHOC2.

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Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome - Nature Structural & Molecular Biology

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Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome - Nature Structural & Molecular Biology

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