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Accelerated enzyme evolution for targeted C–H oxidation in cyclic amines - Nature Synthesis

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Accelerated enzyme evolution for targeted C–H oxidation in cyclic amines - Nature Synthesis

Chemical reagents readily oxidize alkyl amines at sites adjacent to nitrogen. Achieving selective oxidation at specified non-adjacent sites is much more challenging. A computation-guided process is introduced that enables rapid optimization of enzymes for site-selective hydroxylation of a variety of cyclic amines.

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Accelerated enzyme evolution for targeted C–H oxidation in cyclic amines - Nature Synthesis

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Accelerated enzyme evolution for targeted C–H oxidation in cyclic amines - Nature Synthesis

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