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A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer - Cancer Gene Therapy

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A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer - Cancer Gene Therapy

The chromatin-modifying enzyme ATAD2 confers oncogenic competence and proliferative advantage in malignances. We previously identified ATAD2 as a marker and driver of cell proliferation in ovarian cancer (OC); however, the mechanisms whereby ATAD2 is regulated and involved in cell proliferation are still unclear. Here, we disclose that ATAD2 displays a classical G2/M gene signature, functioning to facilitate mitotic progression.

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A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer - Cancer Gene Therapy

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A targetable MYBL2-ATAD2 axis governs cell proliferation in ovarian cancer - Cancer Gene Therapy

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Unlocking the Power of Knowledge
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