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SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation - Cancer Gene Therapy

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SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation - Cancer Gene Therapy

SET and MYND domain-containing protein 3 (SMYD3), a known histone methyltransferase, was reported to regulate cancer pathogenesis. However, its role in gastric development and progression remains unclear. EZH2 methylation had been associated with cancer metastasis, but the EZH2 methylation status in gastric cancer (GC) is unknown. Here, we report that EZH2 K421 methylation was responsible for gastric cancer cell soft agar colony formation, in vivo metastasis, and macrophage polarization.

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SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation - Cancer Gene Therapy

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SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation - Cancer Gene Therapy

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