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Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy - Cell Death & Differentiation

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Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy - Cell Death & Differentiation

Potassium (K+) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K+ channel KCNB1 (Kv2.1) in neocortical development. Neuronal migration of glutamatergic neurons was impaired in the neocortices of KCNB1 null mice. Migratory defects persisted into the adult brains, along with disrupted morphology and synaptic connectivity.

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Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy - Cell Death & Differentiation

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Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy - Cell Death & Differentiation

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