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Skin chronological aging drives age-related bone loss via secretion of cystatin-A - Nature Aging

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Skin chronological aging drives age-related bone loss via secretion of cystatin-A - Nature Aging

Although clinical evidence has indicated an association between skin atrophy and bone loss during aging, their causal relationship and the underlying mechanisms are unknown. Here we show that premature skin aging drives bone loss in mice. We further identify that cystatin-A (Csta), a keratinocyte-enriched secreted factor, mediates the effect of skin on bone.

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Skin chronological aging drives age-related bone loss via secretion of cystatin-A - Nature Aging

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Skin chronological aging drives age-related bone loss via secretion of cystatin-A - Nature Aging

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