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Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9 - Nature Catalysis

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Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9 - Nature Catalysis

At the core of the CRISPR–Cas9 genome-editing technology, the endonuclease Cas9 introduces site-specific breaks in DNA. However, precise mechanistic information to ameliorate Cas9 function is still missing. Here, multimicrosecond molecular dynamics, free energy and multiscale simulations are combined with solution NMR and DNA cleavage experiments to resolve the catalytic mechanism of target DNA cleavage.

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Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9 - Nature Catalysis

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Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9 - Nature Catalysis

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