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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A - Nature Cell Biology

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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A - Nature Cell Biology

The biological purpose of long non-coding RNAs (lncRNAs) is poorly understood. Haploinsufficient mutations in HNF1A homeobox A (HNF1A), encoding a homeodomain transcription factor, cause diabetes mellitus. Here, we examine HASTER, the promoter of an lncRNA antisense to HNF1A. Using mouse and human models, we show that HASTER maintains cell-specific physiological HNF1A concentrations through positive and negative feedback loops.

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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A - Nature Cell Biology

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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A - Nature Cell Biology

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