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Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance - Nature Metabolism

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Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance - Nature Metabolism

Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy metabolism to microglial function in AD remains unclear. Here, we demonstrate that hexokinase 2 (HK2) is elevated in microglia from an AD mouse model (5xFAD) and AD patients.

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Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance - Nature Metabolism

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Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance - Nature Metabolism

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