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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature

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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature

Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)1–6. However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains unclear. Here we show that the production of BHB is impaired in individuals with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) but not in those with influenza-induced ARDS.

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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature

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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature

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